Biomedical Applications of Extracellular Vesicles
Unique resource focusing on biomedical applications and clinical translation of extracellular vesicles in science and medicine
Focusing on key points to better understand extracellular vesicles (EVs) and their development,
describes in detail the biogenesis of EVs, the mechanism of intercellular communication, and the treatment of various diseases of EVs and the EV-based drug delivery platforms. An application-oriented resource, the work presents rapidly newer biomedical and clinical applications of natural and engineered EVs such as drug delivery, diagnosis, prognosis monitoring, immunotherapy, and more.
The first part of this book provides a basic background on EVs. Next, the book introduces the excellent therapeutic effects of EVs themselves and the underlying mechanisms, followed by how EVs from different sources were used to construct drug delivery platforms. The latest research on EVs from leading groups around the world is presented.
Sample topics covered in
include:
Biogenesis of various EVs
Pros and cons of the different instrumental and methodological developments for analytical strategies applied to EVs
EVs in treatment of major diseases, such as cancer, cardiovascular and respiratory diseases
Current methods of engineering EVs, and a comparison of the advantages and disadvantages of each method
Biomaterials, such as hydrogels, scaffolds, and microneedles, that have been developed to further enhance the therapeutic efficacy of EVs
Key challenges, such as quality control, scalability, and biosafety, that limit the clinical and industrial translation of EVs
Explaining in detail how extracellular vesicles are produced and engineered, along with potential applications and commercial developments of EVs in science and industry,
is an essential resource on the subject for chemists, cell biologists, and molecular physicists.