Periodontal regeneration is a field of dentistry focused on restoring and regenerating the tissues that support the teeth, including the gums, periodontal ligament, and alveolar bone. Recent advancements in periodontal regeneration have aimed to improve treatment outcomes, enhance tissue healing, and provide more effective and predictable results for patients with periodontal diseases. The restoration of missing tooth-supporting tissues, such as the periodontal ligament, alveolar bone, and cementum, has been the focus of numerous regenerative periodontal therapies over the past 20 years, including guided tissue regeneration (GTR), enamel matrix derivative, bone grafts, growth factor delivery, and the combination of cells and growth factors with matrix-based scaffolds.