A broad perspective has been provided relating to inflammasome-periodontal disease association by including studies focusing on several periodontal pathogens, as well as on the possible modulatory mechanisms that may be involved. However, this book is focuses primarily on single molecule analyses, subsequently a broader picture at all times needs to be considered. In addition, although inflammasomes appear to play a potential role in periodontal disease pathogenesis, corroboration of these findings to validate periodontal disease and inflammasome associations.