The 2nd Annual 2016 International Conference on Mechanical Engineering and Control System (MECS2016) was successfully held in Wuhan, China in 2016.The MECS2016 is one of the leading international conferences for presenting novel and fundamental advances in the fields of Mechanical Engineering and Control System attended by more than 80 participants from China, South Korea, Taiwan, Japan, Malaysia, and Saudi Arabia. The MECS2016 program includes 4 keynote speeches, 98 oral and poster presentations, covering a wide spectrum of topics from mechanics engineering, control engineering and technology, to automation and mechatronics. However, after reviewed and careful consideration, only 70 articles are included in this proceedings.