It is almost the year of the millennium, and Melissa meets her college friends Sarah and Doug and her first and only true love John for a reunion in Hyde Park. All four are in the midst of their careers. All struggle with the compromises that have marred their happiness. All wish to change the world, each in a different way. Sarah has left her government job for a new life as a yoga teacher. Doug is helping to birth a new value-based economy. John is a successful academic doctor. Melissa is ailing. They unite to turn John's success as a researcher to the cure of Melissa's mysterious chronic illness. What they find will change their lives and their imperiled world.